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For the short-term treatment of postoperative pain in adults age 18 and over.'
A compelling choice for the short-term management of postoperative pain
- Fast, long-lasting relief of moderate-to-severe postoperative pain
- Rapid onset from 7-13 minutes:1 peak effect within 2 hours (IM or IV)1
- Long duration: up to 11 hours in hernia repair2 and from >5 to 8.7 hours in a variety of surgical procedures after a single dose3,4
- Can be used with opioids as part of a multimodal approach1
- Significant reductions in cumulative opioid use vs placebo in a variety of surgical procedures (p<0.05)5-7
- An established tolerability profile
- Little to no effect on bleeding time or platelet aggregation8
- Incidence of gastrointestinal ulcers/erosions significantly lower than with NSAIDs1,9
- In one study, 5-21% gastroduodenal ulcers or erosions with parecoxib vs 66-90% with NSAIDs, and 10% duodenal ulcer/erosion with parecoxib vs 45% with an NSAID (p<0.05 for both)9
- Convenient twice daily IV or IM dosing1
- Can be administered preoperatively, intraoperatively and postoperatively
An injectable COX-2 selective NSAID indicated for the short-term management of postoperative pain in adults1
COX: cyclooxygenase; IV: intravenous; IM: intramuscular; NSAID: nonsteroidal anti inflammatory drug
- Pfizer Ltd. Dynastat 40 mg Powder for Solution for Injection. Summary of Product Characteristics.
- Kyriakidis AV, et al. Hernia. 2011;15:59–64.
- Barden J, et al. BMC Anesthesiology. 2003;3:1.
- Malan TP Jr, et al. Anesth Analg. 2005, 100:454–460.
- Malan TP Jr, et al. Anesthesiology, 2003; 98:950-956.
- Hubbard RC, et al. Br J Anaesth. 2003;90(2):166–72.
- Essex MN, et al. Int J Gen Med. 2017; 10:319-327.
- Noveck RJ, et al. Clin Drug Invest. 2001;21:465–76.
- Stoltz RR, et al. Am J Gastroenterol. 2002;97:65–71.